OLIGONUCLEOTIDES CONTAINING THIOL-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF

摘要

The present invention provides C-5 thiol-substituted nucleosides such as C-5 thiopropyne-substituted thymidine derivatives and oligonucleotides containing such derivatives. The presence of the nucleoside derivatives in a linear oligonucleotide allows the formation of covalent cross-links between noncomplementary DNA domains.