PROCESS FOR 9-AMINOCAMPTOTECIN INTERMEDIATE COMPOUNDS, PROCESS FOR PREPARATION OF THEREOF, PHARMACEUTICAL COMPOSITION

摘要

FIELD: medicine. SUBSTANCE: claimed invention describes process for preparing 9- aminocamptotecin of formula (I):comprises reacting compound of formula III:wherein hydroxy group at ring A is position 10 or 12 with nitrating agent to give respective compound of formula (IV):, converting compound of formula of formula V:wherein XO is group which can be removed by reduction and reductive removal of the XO-group and reduction of nitro group of compound of formula (V) to give 9-aminocamptotecin of formula I which is well known antitumor compound. The claimed invention also describes compound of formula V given above and compound of formula VII:which has antitumor activity. EFFECT: improved properties of the pharmaceutical composition.