发明名称 |
Mhc-class ii restricted melanoma antigens and their use in therapeutic methods |
摘要 |
The present invention provides MHC Class II restricted melanoma antigens recognized by CD4<SUP>+</SUP> T cells. This invention further provides prophylactic and therapeutic applications for the Class II restricted melanoma antigens. In particular, this invention provides tyrosinase Class II restricted melanoma antigens, as well as tyrosinase immunogenic peptides which have been modified to enhance their immunogenicity. These antigens can serve as an immunogens or vaccines to prevent or treat melanoma. In addition a method for isolating Class II restricted melanoma antigens or identifying new Class II restricted melanoma antigens is provided. |
申请公布号 |
AU7245296(A) |
申请公布日期 |
1997.04.17 |
申请号 |
AU19960072452 |
申请日期 |
1996.09.25 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
SUZANNE L. TOPALIAN;STEVEN A ROSENBERG;PAUL F ROBBINS |
分类号 |
A61K38/00;C07K14/74;C12N9/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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