| 摘要 |
PCT No. PCT/JP96/02669 Sec. 371 Date Mar. 13, 1998 Sec. 102(e) Date Mar. 13, 1998 PCT Filed Sep. 18, 1996 PCT Pub. No. WO97/11069 PCT Pub. Date Mar. 27, 1997This invention relates to a compound of formula (I) wherein A1 is lower alkylene, R1 is substituted quinolyl, etc., R2 is hydrogen, halogen or lower alkyl, R3 is halogen or lower alkyl, and R4 is a group of the formula: -Q-A2-R5, etc., in which R5 is amino, acylamino, etc., A2 is lower alkylene or a single bond, and Q is a group of formula (a), and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals. |
