| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new derivative which is a specific ursodeoxycholic aid derivative, useful as a therapeutic agent for internal organ inflammations, inflammatory intestinal disease, etc., having scavenging action and formation inhibiting action on superoxide dismutase, inhibitory action on neutrophile migration and low in toxicity. SOLUTION: This new ursodeoxycholic acid derivative (salt) is shown by the formula (R<1> and R<2> are each H, phosphono, sulfo or acetyl), has scavenging action and formation inhibiting action on superoxide dismutase, scavenging action on a free radical, suppressing actions on production of lipid peroxide, biosynthesis of leukotriene B4 , neutrophile migration, immunological action and inflammatory cytokinin and is useful as an active ingredient of a therapeutic agent for internal organ inflammations, inflammatory intestinal disease, etc. The compound is obtained by dissolving 3α,7β-dihydroxycholan-24-oic acid in an organic solvent, reacting the solution with N,N'-carbonyldiimidazole, reacting the resultant substance with 5-aminosalicylic acid, etc., and precipitating the formed substance by adding hydrochloric acid.
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