ANTAGONISTS OF ENDOTHELIN RECEPTORS

摘要

The present invention provides novel compounds represented by general formula (I), wherein (i) R1 represents 1,2,4-triazol-1-yl, R2 represents methyl or hydroxy, R3 represents methyl or hydroxy, and the asterix means that the chiral carbon atom to which said asterix is attached has the (D) or (D,L) configuration, or (ii) R1 represents isoxazol-5-yl, R2 is methyl, R3 is methyl, and the asterix means that the chiral carbon atom to which said asterix is attached has the (D) configuration; and salts thereof; processes for the manufacture, pharmaceutical compositions and the use of the compounds of formula (I) and salts thereof.