A method for the inhibition and amelioration of alcoholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.
申请公布号
WO9711708(A1)
申请公布日期
1997.04.03
申请号
WO1996US15861
申请日期
1996.09.27
申请人
EISAI RESEARCH INSTITUTE
发明人
ROSSIGNOL, DANIEL, P.;THURMAN, RONALD, G.;CHRIST, WILLIAM, J.;LEWIS, MICHAEL, D.