发明名称 |
Method of preparing gram-negative bacterial vaccines |
摘要 |
PCT No. PCT/US92/09944 Sec. 371 Date Jul. 11, 1994 Sec. 102(e) Date Jul. 11, 1994 PCT Filed Nov. 13, 1992 PCT Pub. No. WO93/10216 PCT Pub. Date May 27, 1993There is provided by this invention a novel method of preparing Gram-negative bacterial vaccines. The method comprises providing a concentrated Gram-negative bacterial antigenic preparation,adsorbing the preparation with a mineral carrier capable of binding free-endotoxin in the antigenic preparation in an amount effective to produce optimal binding of endotoxin and antigen and diluting the adsorbed preparation for use in a vaccine. Also provided by this invention is a vaccine produced by the method of this invention. Also provided by this invention is a Gram-negative bacterial vaccine wherein the improvement comprises a concentration of mineral carrier in the vaccine which is less than 5.0% v/v. Also provided by this invention is a Gram-negative bacterial vaccine comprising a mineral carrier wherein the amount of the mineral carrier in the vaccine has been predetermined by the method of this invention. Also provided by this invention is a method of vaccinating an animal against Gram-negative bacterial infections comprising administering to the animal an effective amount of a vaccine of this invention.
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申请公布号 |
US5616328(A) |
申请公布日期 |
1997.04.01 |
申请号 |
US19940240649 |
申请日期 |
1994.07.11 |
申请人 |
PFIZER INC. |
发明人 |
ROBERTS, DAVID S.;DEARWESTER, DONALD A.;SWEARINGIN, LEROY A. |
分类号 |
A61K39/02;A61K39/102;(IPC1-7):A61K39/112;A61K39/10;A61K39/108;C07K1/00 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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