发明名称 |
BENZENEDIMETHANOL SUITABLE FOR MICRONISATION. |
摘要 |
<p>1-Hydroxy-2-naphthalene carboxylate (hydroxynaphthoate) salt of 4-hydroxy- alpha <1>-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3- benzenedimethanol in the form of spherical accretions of microcrystals, the spherical accretions being free-flowing, friable and micronisable and preferably having a mean particle size from 70 to 300 mu m and a mean surface area from 4 to 12m<2>g-<1>. The hydroxynaphthoate salt (in the claimed form) may be prepared by quenching a hot organic/aqueous organic solution containing the salt with a cold organic/aqueous organic solvent.</p> |
申请公布号 |
GR3022088(T3) |
申请公布日期 |
1997.03.31 |
申请号 |
GR19960403534T |
申请日期 |
1996.12.18 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
BEACH, STEVEN, FREDERICK;LATHAM, DAVID, WILLIAM, STUART;ROBERTS, TONY, GORDON;SIDGWICK, COLIN, BRIAN |
分类号 |
C07C271/10;A61K9/12;A61K9/14;A61K9/16;A61K31/135;A61P11/00;A61P31/00;B02C19/06;C07C65/11;C07C65/28;C07C69/94;C07C213/00;C07C213/08;C07C217/10;C07C323/62;(IPC1-7):C07C217/10 |
主分类号 |
C07C271/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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