发明名称 |
Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic liposomes |
摘要 |
<p>Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic oligolamellar liposomes, the wall of which consists of lipids and optionally a substance A and the core of which consists of water or an aqueous solution, and optionally containing a substance B, characterised in that: (1) a liquid phase is prepared, consisting essentially of a solution of the lipids and optionally of the substance A in a solvent or in a solvent mixture, and which can contain the substance B in solution, (2) a second liquid phase is prepared, consisting essentially of water or an aqueous solution of the substance B, (3) the first phase is added with moderate agitation to the second phase so as to obtain a colloidal suspension of liposomes and (4) if so desired, all or part of the solvent or solvent mixture and water is removed so as to obtain a colloidal suspension having the desired liposome concentrations. Applications: medicinal products, cosmetic products.</p> |
申请公布号 |
GR3022121(T3) |
申请公布日期 |
1997.03.31 |
申请号 |
GR19960403555T |
申请日期 |
1996.12.20 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
STAINMESSE, SERGE;FESSI, HATEM;DEVISSAGUET, JEAN-PHILIPPE;PUISIEUX, FRANCIS |
分类号 |
A61K8/11;A61K8/14;A61K8/34;A61K9/127;B01J13/02;(IPC1-7):A61K9/127 |
主分类号 |
A61K8/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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