| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new antineoplastic material manifesting antineoplastic effects even in various tumors on which an ordinary antineoplastic agents can not manifest their effects. SOLUTION: This material is a compound expressed in formula (R<1> is OH or a hydrazino; R<2> is H or methyl). This compound is obtained by aerobic culture of a microorganism or its variant, such as streptomyces sp A4230, in a culturing medium like yeast, malt agar and collecting. The culturing condition is at 22-37 deg.C (preferably 26-37 deg.C), at 4-8pH of and for 48-192 hours (preferably 72-144 hours). |
