| 摘要 |
This invention is a method of producing schistosomes as an intermediate transgene vector for secretion of desired gene products. The desired products are secreted into the bloodstream of the host (patient) by schistosomes that have been engineered through the germline with DNA encoding the transgene. The use of schistosomes as an intermediate vector facilitates mass production, quality control, termination of therapy at will and dose titration. The method is applicable to situations in which the acquired protein is functional in the plasma or in endocytotic vesicles.
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