New N-(substd. tert. alkyl)-3-substd. pyrrolinone derivs.

摘要

N-substd. pyrrolinone derivs. of formula (I) are new. A = H, halo, 1-6C alkyl (opt. substd. by halo or 1-6C alkoxy), or Z; Z = OR4, SR4, SOR4, SO2R4 or NR5R6; R1 = Z; R2 = H, 1-6C alkyl, 1-6C alkoxy, halo, OH, NH2, 1-6C alkylamino or 1-6C dialkylamino; R3 = H, 1-6C alkyl or halo; R4, R6 = H, 1-6C alkyl (opt. substd. by halo or 1-6C alkoxy), 2-6C alkenyl, 2-6C haloalkenyl, 3-6C alkynyl, 3-6C cycloalkyl, Ar, CH2Ar or COR7; R5 = as R4 , OH or 1-6C alkoxy; or NR5R6 = pyrrolidino, piperidino or morpholino; Ar = phenyl (opt. substd. by Xm); R7 = H, 1-6C alkyl, 1-6C haloalkyl, 3-6C cycloalkyl or Ar; X = H, OH, 1-6C alkyl, 1-6C haloalkyl, 1-6C alkoxy-1-6C alkyl, 1-6C alkoxy, 1-6C haloalkoxy, SH, 1-6C alkylthio, 1-6C alkylsulphonyl, 1-6C alkylsulphinyl, NH2, 1-6C alkylamino, 1-6C dialkylamino, halo, CN, 1-6C alkoxycarbonyl, aminocarbonyl, 1-6C alkylaminocarbonyl, 1-6C dialkylaminocarbonyl or NO2; E = CO-R8, C(NOR9)R8, pyridyl, or a gp. of formula (a)-(c), all opt. substd. by Xm; Q = CH, or one Q is CH and the other is N; D = O, S, NH, or N-1-6C alkyl; R8 = H, OH, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, Ar, CH2Ar, OR9, OM or NR10R11; R9 = H, 1-6C alkyl, benzyl or phenyl (opt. substd. by 1-6C alkyl, 1-6C alkoxy, halo or NO2); R10, R11 = H, OH, 1-6C alkyl, 2-6C alkenyl, 3-6C alkynyl, 1-6C alkoxy, Ar or benzyl (opt. substd. by Xm); or NR10R11 = pyrrolidino, piperidino or morpholino; M = Li, Na, K, Zn, Mn, Ca, Ba or NH4.