SYSTEM FOR RENDERING SUBSTANTIALLY NON-DISSOLUBLE BIO-AFFECTING AGENTS BIO-AVAILABLE

摘要

The present invention is a method of preparing a system for delivering a bioaffecting agent and the composition prepared thereby. The invention includes forming a solid dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a watersoluble polymer, the bio-affecting agent is made available ("bio-available") to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially nonsoluble drugs and other bio-affecting ingredients.