VIRUS PROTEIN PURIFICATION FROM VIROSOMES

摘要

The invention provides purification methods and crystallized viral attachment protein (VAP) of virosomes derived from a virus, wherein (a) the crystallized VAP is suitable for x-ray crystallography analysis; (b) x-ray analysis provides diffraction patterns of sufficient resolution to determine the three-dimensional structure of the VAP; (c) the crystallized VAP is in biologically active form, as well as a specific crystallized VAP, hemagglutinin neuraminidase (HN) from a strain of Paramyxovirus, including nucleic acid, vectors and host cells having nucleotide sequences encoding the HN.