发明名称 |
Process for preparing intermediates for thrombin inhibitors |
摘要 |
A process is provided for preparing intermediates of the structure <IMAGE> wherein Rpg is preferably =CHC6H5; and P.G. is a protecting group CBZ or BOC, wherein a protected guanylpyrazole is reacted with an azacycloalkyl, azacycloalkenyl or azaheteroalkyl derivative (such as a piperidine derivative) in the presence of a DBU catalyst. The resulting intermediate may be used as a starting material for preparing thrombin inhibitors.
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申请公布号 |
US5610308(A) |
申请公布日期 |
1997.03.11 |
申请号 |
US19950443960 |
申请日期 |
1995.05.18 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
REAL, SHARON D.;KRONENTHAL, DAVID R. |
分类号 |
C07D243/08;A61K38/00;A61K38/55;A61P7/02;A61P9/08;A61P9/10;A61P25/28;A61P31/04;A61P43/00;C07D207/16;C07D211/26;C07D211/28;C07D267/10;C07D281/18;C07K5/065;(IPC1-7):C07D211/60 |
主分类号 |
C07D243/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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