| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new antibody for diagnosing, preventing and treating JC virus infectious diseases, capable of specifically recognizing JC virus by using a peptide fragment having a specific amino acid sequence which is a part of VP-1 protein of JC virus as an antigen. SOLUTION: This anti JC virus antibody is a new anti-JC virus antibody obtained by using a peptide fragment which is a part of VP-1 protein of JC virus and has an amino acid sequence expressed by the formula as an antigen and is useful for diagnosis, prevention and treatment of JC virus infectious diseases and prevention and treatment, etc., of progressive multifocal leukoencephalopat(PML), dementia, etc. The antibody is obtained by synthesizing a peptide fragment having an amino acid sequence expressed by the formula by a solid phase synthesis, etc., injecting the peptide fragment into the subcutis of rat together with Freund' s complete adjuvant to immunize the rat, administering antigen and adjuvant as an additional immune at an interval of 2 weeks, collecting a serum at a point of time at which antibody titre in the serum is raised and separatingγ-globulin fraction from the serum.
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