发明名称 |
STRUCTURAL MIMICS OF RGD-BINDING SITES |
摘要 |
The present invention provides cyclic peptides that recognize the arginine-glycine-aspartic acid (RGD) motif characteristic of many integrin ligands. These cyclic RGD-binding peptides, which comprise the motif (W/P)DD(G/L)(W/L)(W/L/M), have a structure that functionally mimics the RGD-binging site on an integrin. The invention further provides an antibody selectively reactive with a cyclic RGD-binding peptide containing the sequence (W/P)DD(G/L)(W/L)(W/L/M). The invention also provides a method to reduce or inhibit cell attachment to an RGD-containing ligand using a cyclic RGD-binding peptide of the invention.
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申请公布号 |
WO9708203(A1) |
申请公布日期 |
1997.03.06 |
申请号 |
WO1996US14058 |
申请日期 |
1996.08.26 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
RUOSLAHTI, ERKKI;PASQUALINI, RENATA |
分类号 |
A61K38/00;C07K14/705;C07K16/28;(IPC1-7):C07K14/705;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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