| 摘要 |
The following are claimed: (1) a form of nizatidine which contains N,N`-bis(2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl)-2-nitro-1, 1-ethenediamine (I) and N, N`-dimethyl-2-nitro-1, 1-ethenediamine (II) but not N-methyl-1-methylthio-2-nitro-ethyleneamine (III); (2) a process for preparing a form of nizatidine, comprising heating nizatidine contg. (III) in the presence of water to remove (III); (3) the form of nizatidine produced by the process of (2); (4) a pharmaceutical compsn. contg. nizatidine which has been heated in the presence of water to remove (III); and (5) a pharmaceutical compsn. contg. nizatidine in the form of (1). Nizatidine is N-(2-(2- dimethylaminomethyl-4- thiazolylmethylthio)ethyl)-N`-methyl-2-nitro-1, 1-ethenediamine. |
