发明名称 |
CONTROL OF CD44 GENE EXPRESSION FOR THERAPEUTIC USE |
摘要 |
Neoplastic cells which over-express CD44, including especially non-small cell lung cancer and melanoma cancer cells, are treated with antisense oligonucleotides to control CD44 expression. Test results show that the claimed oligonucleotides significantly decreases cell growth in a CD44 sequence specific manner of lung cancer or melanoma cells, or both, but are largely non-toxic to normal cells. Examples of dosing in a clinical setting are provided.
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申请公布号 |
CA2228965(A1) |
申请公布日期 |
1997.02.27 |
申请号 |
CA19962228965 |
申请日期 |
1996.07.31 |
申请人 |
ICN PHARMACEUTICALS |
发明人 |
RUZDIJIC, SABERA;PIETRZKOW, ZBIGNIEW;DARIUSZ, CIESLAK |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P35/00;C12N15/113;(IPC1-7):C07H21/04;C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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