| 发明名称 |
Use of agonists or antagonists of p<sub>2</sub> purinoceptorsfor the prevention of glutamate-evoked cytotoxicity |
| 摘要 |
This invention relates to the use of agonists or antagonists of P2 purinoceptors for the prevention of glutamate-evoked cytotoxicity and in particular use of Basilen Blue D-3G (Reactive Blue 2), Cibacron Blue 3GA and 5-adenylylimidodiphosphate (AMPPNP). In the presence of cytotoxic concentrations of glutamate, these compounds sustain cellular survival of central nervous system (CNS) neurons, such as for example postnatal rat cerebellar granule neurons. |
| 申请公布号 |
AU6736696(A) |
申请公布日期 |
1997.02.26 |
| 申请号 |
AU19960067366 |
申请日期 |
1996.07.24 |
| 申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
CINZIA VOLONTE';DANIELA MERLO |
| 分类号 |
C07D251/50;A61K31/00;A61K31/53;A61K31/70;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7076;A61K45/00;A61K45/06;A61P5/00;A61P9/00;A61P25/00;A61P25/04;A61P25/28;A61P39/00;A61P39/02;A61P43/00;C07H19/20 |
主分类号 |
C07D251/50 |
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