| 摘要 |
PCT No. PCT/SE94/00480 Sec. 371 Date Nov. 22, 1995 Sec. 102(e) Date Nov. 22, 1995 PCT Filed May 24, 1994 PCT Pub. No. WO94/28416 PCT Pub. Date Dec. 8, 1994A method of determining the affinity and kinetic properties of low molecular weight ligands for their interaction with a common receptor comprises the steps of immobilizing the receptor on a sensing structure, mixing in known proportions each ligand with a ligand analogue the response of which on the sensing structure is substantially higher than that of the low molecular weight ligands, contacting each mixture with the sensing structure and measuring the response, and comparing the response of each mixture with that of the ligand analogue alone, the distortion of the ligand analogue response being representative of the affinity and kinetic properties of the ligand./! |
