NON-RECEPTOR TYPE HUMAN PROTEIN TYROSINE PHOSPHATASE

摘要

The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat PRL-1 derived from human mast cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode HPRL, hybridization probes or oligonucleotides for the detection of HPRL-encoding nucleotide sequences, and a diagnostic test based on HPRL-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HPRL, biologically active HPRL, antibodies against HPRL, inhibitors and agonists of HPRL, and treatment methods comprising administration of compounds, such as antibodies, inhibitors or agonists.