N-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES WITH AMIDE GROUPS

摘要

A benzimidazole derivative of structural formula(I) is prepared by the following two methods. (A) The sulfur atom is oxidized by starting material of structural formula(II) to produce a compound of structural formula(III) in oxidization, substitution or condensation reaction. (B) A compound of structural formula(II) is substituted by hydroxyalkyl, alkoxycarbonyl or like to produce a compound of structural formula(IV), and then oxidized. In the above formula, R1 is low-level alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl or like as substituents introduced by substitution or condensation reaction. R2 is alkyl, alkoxy group including hydrogen atom, methyl group. R3, R4, R5 are hydrogen atom where C1~C3 is alkoxy group and n is 0 or 1.