PROCESS FOR PROTEIN REFOLDING BY MEANS OF BUFFER EXCHANGE USING A CONTINUOUS STATIONARY PHASE CAPABLE OF SEPARATING PROTEINS FROM SALTS

摘要

Disclosed is a quick and efficient refolding process which utilizes cellulosic rolled stationary phase to rapidly separate the reduced, denatured protein from the denaturant solution, thereby promoting high protein refold yields at higher protein concentrations, while significantly decreasing the volume needed to achieve protein refolding.