| 摘要 |
PCT No. PCT/US92/09752 Sec. 371 Date May 9, 1994 Sec. 102(e) Date May 9, 1994 PCT Filed Nov. 6, 1992 PCT Pub. No. WO93/09143 PCT Pub. Date May 13, 1993Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization.
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