发明名称 |
Immunogenic four amino acid epitope against Plasmodium vivax |
摘要 |
An agent and pharmaceutical formulations of the agent containing a synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human malaria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented.
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申请公布号 |
US5599543(A) |
申请公布日期 |
1997.02.04 |
申请号 |
US19920848636 |
申请日期 |
1992.03.09 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
HOFFMAN, STEPHEN L.;CHAROENVIT, YUPIN;JONES, TREVOR R. |
分类号 |
A61K39/00;C07K5/103;C07K14/445;(IPC1-7):A61K39/015 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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