Triarylmethyl radicals and the use of inert carbon free radicals in MRI

摘要

PCT No. PCT/EP91/00285 Sec. 371 Date Sep. 2, 1992 Sec. 102(e) Date Sep. 2, 1992 PCT Filed Feb. 12, 1991 PCT Pub. No. WO91/12024 PCT Pub. Date Aug. 22, 1991A radical compound of formula Ia.C(Ar12)3(Ia)wherein: each Ar12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar12 being a group Ar1; each group Ar1 represents a 6-membered ring optionally substituted at the or any ortho carbon by a group R1, R2, R3 or R4, at the or any meta carbon by a group R2 or R3, and at any para carbon by a group R1, R2, R3 or R4, with the proviso that no more than two ring carbons are unsubstituted; each of R1, R2, R3 or R4, which may be the same or different, independently represents a group of formula -M, -XM, -XAr2 or -Ar2; M represents a water solubilizing group, each group X, which may be the same or different, represents an oxygen or sulphur atom or a NH or CH2 group.