Use of 1,4-dihydropyridine derivatives in the prevention and therapy of atherosclerotic degradation of arterial walls

摘要

1,4-Dihydropyridines have been found to counter several processes which play a role in the development of atherosclerotic vascular lesions, such as myocytes proliferation and migration, cholesterol metabolism in macrophages and oxidative modification of low density lipoproteins. They are therefore useful in the manufacture of medicaments for preventing, arresting and reversing atherosclerotic degradation in the arterial walls of humans. The preferred 1,4-dihydropyridines for this purpose are lercanidipine, (S)-lercanidipine and (R)-lercanidipine.