发明名称 |
INTERACTION OF P53 WITH TRANSCRIPTION FACTOR DP-1 |
摘要 |
Complexes of p53 with the transcription factors DP-1 (and other members of the DP family) or E2F-1 (or other E2F proteins, up to and including E2F-5), are disclosed. These novel complexes can be used to assay for potential chemotherapeutic agents that are p53 agonists or antagonists, particularly agonists or antagonists which modulate progression through the cell cycle by disruption of the normal binding of p53 to DP-1 and/or E2F-1.
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申请公布号 |
CA2224940(A1) |
申请公布日期 |
1997.01.23 |
申请号 |
CA19962224940 |
申请日期 |
1996.06.28 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
LATHANGUE, NICHOLAS BARRIE |
分类号 |
C12N15/09;A61K31/70;A61K35/76;A61K38/00;A61K48/00;A61P35/00;C07K14/47;C07K14/82;C07K19/00;C12N5/10;C12N15/12;C12N15/83;(IPC1-7):C12N15/12;C12Q1/02;G01N33/566;G01N33/574;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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