| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new cyclic diamine derivative useful for treating a hypersensitive intestinal syndrome, etc., having selectivity in other smooth muscle muscarine higher than in cardiac muscarine and strong antagonism. SOLUTION: This compound is shown by formula I (R<1> and R<2> are each phenyl, pyridyl, etc.; R<3> is H or a lower alkyl; R<4> and R<5> are each independently H, a lower alkyl, etc.; R<6> and R<7> are each independently H, a lower alkyl, etc.; R<8> is H, halogen, etc.; Z is C or N; (m) is 1, 2, 3, or 4; (n) is 1, 2 or 3; (p) is 0, 1, 2 or 3) such as 2,2-diphenyl-4-[5-(4-fluorobenzyl)-2,5- diazabicyclo[2,2,2]octan-2-yl]butyronitrile. The compound of formula I is obtained by reacting a compound of formula II (X is an eliminable group) with a compound of formula III preferably at 60-150 deg.C. |
