| 摘要 |
<p>Compounds of formula (I) wherein A1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R?3 or R4; X1-X2 is CHR1-CH, CR1=CH, NR1¿-CH, S(O)¿u?-CH or O-CH; X?3 is CR5R5', NR5¿, S(O)¿u? or O; R?2¿ is -OR', -NR'R', -NR'SO¿2?R'', -NR'OR', -OCR'2C(O)OR', -OCR'2OC(O)-R', -OCR'2C(O)NR'2, CF3 or -COCR'2R?2'; R3, R4 and R7¿ are independently H, halo, -OR?12, -SR12¿, -CN, -NR'R12, -NO2, -CF3, CF3S(O)r-, -CO2R', -CONR'2, R14-C0-6alkyl-, R14-C1-6oxoalkyl-, R14-C2-6alkenyl-, R14-C2-6alkynyl-, R14-C0-6alkyloxy-, R14-C0-6alkylamino- or R14-C0-6alkyl-S(O)r-; R6 is W-(CR'¿2?)q-Z-(CR'R?10)¿r-U-(CR'2)s-V- or W'-(CR'2)q-U-(CR'2)s- U and V are absent or CO, CR'2, C(=CR152), S(O)n, O, NR?15, CR15'OR15¿, CR'(OR')CR'¿2?, CR'2CR'(OR'), C(O)CR'2, CR?15¿2C(O), CONR?15, NR15¿CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR?15, NR15¿C(S), SO¿2?NR?15, NR15SO¿2, N=N, NR?15NR15, NR15CR15¿2, NR15CR152, CR152O, OCR152, C$(m)ZC, CR15=CR15, Het, or Ar, provided that U and V are not simultaneously absent; and W and W' are a nitrogen-containing substituent, and integrin receptor antagonists.</p> |
