| 摘要 |
PURPOSE: To obtain a novel milbemycin which has acaricidal, insecticidal and vermifugal activities against mites, plant insect pests and animal parasites and as an intermediate for milbemycjin acaricides, insecticides and parasiticides. CONSTITUTION: This compound is represented by formula I (R<1> is ethyl, ethyl; X is OH, Y is H, and R<2> is 3-methyl-2-butenoyl; X is H, Y is OH and R<2> is H, 3-methyl-2-butenoyl), for example, 30-hydroxymilbemycinα11 . The compound of formula I is prepared by culturing a microorganism in Mucor in a culture medium containing a compound of formula II as a substrate or by bringing the cell bodies of the microorganism in Mucor cultured in the medium or an enzyme extract from the culture mixture into contact with the compound of formula II. |
