| 摘要 |
<p>Sialic acid derivatives represented by general formula (1AA) and further derivatives thereof: wherein R1 represents a residue of cholestane or other steroidal compound; R2 represents hydrogen or methyl; R3 represents C¿1?-C6 alkyl, etc.; R?4¿ represents hydrogen or acyl; R5 represents R?15O- (R15¿ being C¿2?-C7acyl) etc.; and X represents oxygen or sulfur. These derivatives have the effect of enhancing a choline acetyltransferase activity in cholinergic neurons and are useful for preventing and treating dementia, memory disorder, peripheral nerve disorder, and so forth.</p> |
