| 发明名称 |
Sequence specific DNA binding by P53 |
| 摘要 |
<p>Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.</p> |
| 申请公布号 |
EP0518650(B1) |
申请公布日期 |
1997.01.08 |
| 申请号 |
EP19920305333 |
申请日期 |
1992.06.10 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY;PHARMAGENICS, INC. |
发明人 |
VOGELSTEIN, BERT;KINZLER, KENNETH W.;SHERMAN, MICHAEL I. |
| 分类号 |
A61B10/00;C07K14/47;C12N15/09;C12P21/08;C12Q1/02;C12Q1/68;G01N33/50;G01N33/53;G01N33/574;G01N33/577;G01N33/68;(IPC1-7):G01N33/574;C12Q1/70;C07H21/04;A61K48/00 |
主分类号 |
A61B10/00 |
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