发明名称 |
Transgenic mice depleted in a mature lymphocytic cell-type |
摘要 |
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
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申请公布号 |
US5591669(A) |
申请公布日期 |
1997.01.07 |
申请号 |
US19950454034 |
申请日期 |
1995.05.30 |
申请人 |
GENPHARM INTERNATIONAL, INC. |
发明人 |
KRIMPENFORT, PAULUS J. A.;BERNS, ANTONIUS J. M. |
分类号 |
A01K67/027;C07K14/725;C07K16/00;C12N15/85;(IPC1-7):C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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