Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
申请公布号
US5591872(A)
申请公布日期
1997.01.07
申请号
US19930104487
申请日期
1993.08.09
申请人
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;UNIV ROCHESTER;ITHACA COLLEGE
发明人
PEARSON, JAMES P.;GRAY, KENDALL M.;PASSADOR, LUCIANO;TUCKER, KENNETH D.;EBERHARD, ANATOL;IGLEWSKI, BARBARA H.;GREENBERG, EVERETT P.