| 摘要 |
A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: wherein A is CO2H, PO2H, or SO2H; B is N; R1 and R2 are H; R3 and R4 are, independently, H, OH, NO2, guanidino, or alkyl or alkenyl of from 1 to 3 carbons where the alkyl or alkenyl is unsubstituted or is substituted, independently, with one or more of OH, NH2, or halide; R5 is H; and R6 is COCH3, or COCI3; or an analog, pharmaceutically acceptable salt, derivative, or mixture thereof. A method of preventing a bacterial or trypanosomal infection using the compounds of formula I. A method of treating a bacterial or trypanosomal infection using the compounds of formula I. A pharmaceutical composition comprising a pharmaceutically acceptable carrier admixed with an inhibiting effective amount of a compound of formula I. A method of making a pharmaceutical composition, comprising admixing a pharmaceutically acceptable carrier with an inhibiting effective amount of a compound of formula I. |
