BRADYKININ ANALOGS AS SELECTIVE THROMBIN INHIBITORS
摘要
Thrombin-induced and ADP-induced platelet and other cell activation is inhibited without affecting thrombin's other proteolytic activity by administration of a bradykinin sequence related analogous peptide. Bradykinin analogs are peptides to which substitutions, additions or deletions have been made to the first four amino acids of the amino acid sequence of native bradykinin. The bradykinin analogs described inhibit alpha -thrombin-induced and ADP-induced platelet activation and secretion, inhibit alpha -thrombin-induced calcium mobilization, and prevent alpha -thrombin from cleaving its platelet receptor. The bradykinin analogs may comprise single- or multiple-chain peptides.
申请公布号
WO9641640(A1)
申请公布日期
1996.12.27
申请号
WO1996US09940
申请日期
1996.06.07
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;SCHMAIER, ALVIN, H.;HASAN, AHMED, A., K.