| 摘要 |
<p>It was found that a collagen peptide fraction (CPF) of especially porcine collagen ⊃70 %, especially ⊃80 %, of which have an average molecular weight of 8-30 kDa, a hydroxyproline content of 15-19 %, a proline content of 18-22 % and a glycine content of 27-33 % which is stable at temperatures up to 150 °C, and shows a viscosity of 2.0 to 3.0 cSt [mm2/sec] at a concentration of 10 % in water and an UV absorbance at 280 nm of 0.6 to 1.8 has a surprising stabilising effect on protein and polypeptides in freeze dried form and in solution. CPF-stabilised proteins and polypeptide drugs can be used during long term infusion or for topical, nasal or transdermal application.</p> |
