Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
申请公布号
WO9621731(A3)
申请公布日期
1996.12.27
申请号
WO1996US00513
申请日期
1996.01.16
申请人
INNOVIR LABORATORIES, INC.;GEORGE, SHAJI, T.;MA, MICHAEL;WERNER, MARTINA;PACE, UMBERTO;GOLDBERG, ALLAN, R.
发明人
GEORGE, SHAJI, T.;MA, MICHAEL;WERNER, MARTINA;PACE, UMBERTO;GOLDBERG, ALLAN, R.