MULTIVALENT BOVINE CORONAVIRUS VACCINE AND METHOD OF TREATING BOVINE CORONAVIRUS INFECTION

摘要

New purified and isolated bovine coronavirus (BCV) types (II and III) are described which can be used to create new modified live vaccines for administration to cattle in order to confer immunity against virulent wildtype bovine coronavirus infection. Preferably, a multivalent modified live vaccine is provided for oral-nasal administration which includes the known Type I virus and the new Types II and III virus. Hygromycin B has also demonstrated to be effective for suppressing replication of the majority of BCV isolates tested and thus can be administered to cattle as a treatment for the chronic disease and to suppress shedding of hygromycin B-sensitive BCV in cattle feces.