| 摘要 |
PURPOSE: To obtain a new peptide having specific amino acid sequences, capable of inhibiting an intercellular adhesion by inhibiting the formation of desmosome which is a cell to cell adhesion device, useful for the prevention and therapy of dermal diseases, and the improvement of troubles in corneum. CONSTITUTION: This intercellular adhesion inhibiting peptide is a peptide or its salt, having amino acid sequences selected from formulas I to IV equivalent to the partial sequences of amino acid sequences of a desmocollin and formula V equivalent to the partial sequences of amino acid sequences of a desmoglein. The peptide is preferably obtained by using a known peptide synthetic method such as a solid phase method and a liquid phase method. The above peptide can be used as a dermal preparation for external use, and blending it by 0.01-30wt.% in the dermal preparation for external use is preferable. As a base used for preparing the dermal preparation for external use, e.g. a vaseline, a paraffin, a polyethylene glycol and water are cited. Also, an emulsifying agent, a suspending agent, a preserving agent, a stabilizing agent, etc., can be blended as necessary. |
