发明名称 |
CHELATING POLYMERS AS CONTRAST AGENTS FOR MEDICAL IMAGING |
摘要 |
The invention provides polymeric polychelants containing polymer repeat units of the formula ¢L-Ch-L-B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R1 relaxivities.
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申请公布号 |
CA2223456(A1) |
申请公布日期 |
1996.12.19 |
申请号 |
CA19962223456 |
申请日期 |
1996.06.03 |
申请人 |
NYCOMED IMAGING A/S |
发明人 |
HENRICHS, PAUL MARK;PENG, XIN;WEI, DONG;KELLER, KENNETH EDMOND;SNOW, ROBERT ALLEN;HOLLISTER, KENNETH ROBERT;LADD, DAVID LEE |
分类号 |
C07D255/02;A61K41/00;A61K49/00;A61K49/08;A61K51/00;A61P39/02;C07D257/02;C07D259/00;C08G63/685;C08G69/48;(IPC1-7):C08G69/48;A61K51/06;A61K31/16;A61K31/21;A61K31/395;A61K31/785;C08G63/91 |
主分类号 |
C07D255/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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