TREATMENT AND PREVENTION OF PROSTATIC DISEASE

摘要

The present invention is related to a method for treating and preventing benign prostatic hyperplasia (BPH) and prostatic carcinoma by administering a therapeutically effective amount of a compound which binds to SHBG and antagonizes the SHBG-mediated effects of both estradiol and 5.alpha.-androstan-3.alpha.,17.beta. diol by preventing the binding of estradiol and 5.alpha.androstan-3.alpha.,17.beta. diol. The present invention further relates to the compounds which bind SHBG and prevent the binding of estradiol and 5.alpha.androstan-3.alpha.,17.beta. diol as well as to a method of finding compounds which bind to SHBG and prevent the binding of estradiol