| 摘要 |
A wound treatment material which absorbs wound fluid without overdrying the wound, provides physical cushioning for the wound, and releases an antimicrobial agent (iodine) in a controlled manner to kill harmful micro-organisms without irritating the wound area or adversely affecting would healing. The wound treatment material comprises crosslinked polyvinylpyrrolidone-iodine complex which is water insoluble, but water-absorbent and water-swellable. When the complex or a wound treatment preparation containing the complex is applied to a wound, i.e., becomes hydrated, and an equilibrium is established between the complex and the wound at the wound/complex interface. Iodine is releaed from the crosslinked polyvinylpyrrolidone-iodine complex by a diffusion controlled process which responds to the reduction in concentration of free iodine in the wound fluid in equilibrium with the complex. The greater the rate of iodine depletion in the wound, the greater the rate of iodine release from the polymer-iodine complex. It has been discovered that this diffusion controlled release mechanism can be utilized to deliver antimicrobially effective amounts of iodine to the wound while maintaining the concentration of iodine below the concentration that could cause significant wound irritation or retardation of healing. It has also been found that the moist environment at the wound/complex interface and the physical protective effect (cushioning) offered by the hydrated complex can enhance wound healing. |
