发明名称 |
DELIVERY OF DRUGS TO THE LOWER GI TRACT |
摘要 |
Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition is a unit dosage in the form of a tablet that comprises about 0.01 % by weight to about 10 % by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40 % by weight to about 98 % by weight of a hydrocolloid gum obtainable from higher plants; and about 2 % by weight to about 50 % by weight of a pharmaceutically acceptable binder. The compositions are useful for treating lower GI disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet. |
申请公布号 |
CA2224170(A1) |
申请公布日期 |
1996.12.19 |
申请号 |
CA19962224170 |
申请日期 |
1996.06.07 |
申请人 |
CIBUS PHARMACEUTICAL, INC. |
发明人 |
WONG, DAVID;FRIEND, DAVID R. |
分类号 |
A61K9/20;A61K9/22;A61K9/28;A61K9/34;A61K31/58;A61K38/11;A61K38/22;A61K38/23;A61K38/26;A61K38/27;A61K38/28;A61K47/36;A61P1/00;A61P13/02;A61P15/00;A61P29/00;(IPC1-7):A61K47/36;A61K38/02;A61K38/09;A61K38/19;A61K31/44;A61K31/57 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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