| 摘要 |
PURPOSE: To obtain an enteric coated preparation coated with a fine powdery enteric coating agent while sprinkling a liquid state plasticizer to a solid medicine. CONSTITUTION: This enteric coated preparation is obtained by coating a granular preparation, a powdery preparation or a bulk medicine with a fine powdery enteric coating agent having <=10μm particle diameter (e.g. hydroxypropyl methyl cellulose acetate succinate) while sprinkling a liquid state plasticizer at a room temperature (e.g. triethyl citrate). By the solventless coating not requiring the drying and completed in a short period, the enteric coated preparation having an acid resistance is obtained. Since the drying of solvent is not necessary and the coating time is short, it is possible to shorten the manufacturing process and by the solventless coating, it is possible to apply it to medicines unstable to water and organic solvents. Further, a surfactant, etc., commonly used in an aqueous enteric coating as a dispersing agent, are not necessary.
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