Method for production of optically active (+)-4,4,4-trifluoro-3-(indole-3-)butyric acid

摘要

An optically active (+)-4,4,4-trifluoro-3-(indole-3-)butyric acid is produced by a method characterised in that the method consists essentially of causing 2,2,2-trifluoroethanol to react on a racemic modification 4,4,4-trifluoro-3-(indole-3-)butyric acid thereby forming a reaction solution containing the trifluoroethyl ester of the butyric acid, causing an enzyme having an esterase activity to act on the reaction solution thereby forming an optically active (+)-4,4,4-trifluoro-3-(indole-3-)butyric acid, and thereafter separating the reaction product from the reaction solution.