| 发明名称 |
Method of cleaving specific strands of RNA |
| 摘要 |
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
|
| 申请公布号 |
US5583032(A) |
申请公布日期 |
1996.12.10 |
| 申请号 |
US19930123449 |
申请日期 |
1993.09.17 |
| 申请人 |
THE CLEVELAND CLINIC FOUNDATION AND NATIONAL INSTITUTES OF HEALTH |
发明人 |
TORRENCE, PAUL;SILVERMAN, ROBERT;MAITRA, RATAN;LESIAK, KRYSTYNA |
| 分类号 |
C12N15/09;C07H21/00;C07H21/02;C12N9/16;C12N15/113;(IPC1-7):C02H5/06;C08J3/00;C12Q1/68 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
